cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline

Base Information

• Chemical Name: cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline
• CAS No.: 117918-93-1
• Molecular Formula: C₂₇H₂₅N₃O₂
• Molecular Weight: 423.514
• Mol file: 117918-93-1.mol

Synonyms:cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline

Chemical Property of cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline

There total 7 articles about cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(1-diazoethyl)benzene (22293-10-3) + methyl (E)-2-cyano-3-phenylprop-2-enoate (14533-86-9) → methyl (E)-2-cyano-4,4-diphenyl-2-pentenoate (117918-91-9) + trans-1-cyano-1-(methoxycarbonyl)-2-methyl-2,3-diphenyl-cyclopropane (117918-92-0) + cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline (117918-93-1)

Guidance literature:

In dichloromethane; 1.) -5 to 0 deg C, 2.) room temp., overnight;

DOI:10.1021/jo00264a025

Reference yield:

2,2-diphenylpropanal (22875-82-7) → cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline (117918-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / acetic acid, ammonium acetate / benzene / 17 h / Heating

2: 47 percent / CH₂Cl₂ / 1.) -5 to 0 deg C, 2.) room temp., overnight

With ammonium acetate; acetic acid; In dichloromethane; benzene;

DOI:10.1021/jo00264a025

Reference yield:

2,2-diphenylpropanal (22875-82-7) → trans-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1,1-diphenylethyl)-1-pyrazoline (117918-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / acetic acid, ammonium acetate / benzene / 17 h / Heating

2: 0.9 percent / CH₂Cl₂ / 1.) -5 to 0 deg C, 2.) room temp., overnight

With ammonium acetate; acetic acid; In dichloromethane; benzene;

DOI:10.1021/jo00264a025

upstream raw materials:

(1-diazoethyl)benzene

methyl (E)-2-cyano-3-phenylprop-2-enoate

2,2-diphenylpropanal

2,2-diphenylpropionitrile

Downstream raw materials:

methyl (E)-2-cyano-4,4-diphenyl-2-pentenoate

acetophenonazine