tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate
CAS No.:1459230-20-6
Molecular Formula:C₃₁H₃₃F₃N₄O₄
Molecular Weight:582.623
Hs Code.:

tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Synonyms:tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Suppliers and Price of tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

There total 6 articles about tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1245770-25-5
tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl)carbamate

: 6-bromo-7-methyl-5-phenyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo[2,3-d]pyrimidine

: 1459230-20-6
tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 833481-37-1
4-chloro-5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

: 1459230-20-6
tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 20 - 70 °C / Inert atmosphere

2: sodium hydroxide; water / 1,4-dioxane / 16 h / 100 °C

3: potassium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

4: bromine / N,N-dimethyl-formamide / 0.5 h / 0 °C

5: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; bromine; sodium carbonate; potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1459230-20-6
tert-butyl ((1r,3r)-3-hydroxy-3-methyl-1-(4-(7-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h

1.2: 1 h

2.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 2 h / 20 - 70 °C / Inert atmosphere

3.1: sodium hydroxide; water / 1,4-dioxane / 16 h / 100 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 90 °C

5.1: bromine / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 16 h / 70 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; bromine; iodine; sodium carbonate; potassium carbonate; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;