Technology Process of (2R,3R,4S)-3,5-bis(benzyloxy)-2,4-dimethylpentan-1-ol
There total 4 articles about (2R,3R,4S)-3,5-bis(benzyloxy)-2,4-dimethylpentan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl (2S,3S,4S)-3,5-bis(benzyloxy)-2,4-dimethylpentanoate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran; water;
DOI:10.1021/jo8021583
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: titanium tetrachloride / dichloromethane / 78 °C / Inert atmosphere
2.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 0 °C
4.1: diisobutylaluminium hydride / dichloromethane / -40 °C / Inert atmosphere
With
trifluorormethanesulfonic acid; di-n-butylboryl trifluoromethanesulfonate; titanium tetrachloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; cyclohexane;
1.1: Mukaiyama reaction;
DOI:10.1021/jo2013884
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 0 °C
2: diisobutylaluminium hydride / dichloromethane / -40 °C / Inert atmosphere
With
trifluorormethanesulfonic acid; diisobutylaluminium hydride;
In
dichloromethane; cyclohexane;
DOI:10.1021/jo2013884
