(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

Base Information

Chemical Name:(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol
CAS No.:856765-74-7
Molecular Formula:C₂₂H₂₉NO₄
Molecular Weight:376.437
Hs Code.:

(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H<sub>5</sub>]benzyl-3-(benzyloxy)propan-2S-ol

Synonyms:(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

There total 1 articles about (S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 856765-73-6
S-4-[2H₅]benzyl-5S-(benzyloxymethyl)-oxazolidin-2-one

: 856765-74-7
(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

Guidance literature:: S-4-[2H₅]benzyl-5S-(benzyloxymethyl)-oxazolidin-2-one; With potassium hydroxide; In ethanol; water; at 70 ℃; for 2h;

di-tert-butyl dicarbonate; In ethanol; dichloromethane; water; at 20 ℃; for 2h; pH=7;
DOI:10.1002/jlcr.870

Reference yield: 100.0%

: 856765-74-7
(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

: 856765-75-8
S-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-propan-2S,3-diol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 18h;
DOI:10.1002/jlcr.870

Reference yield:

: 856765-74-7
(S)-1-[N-(tert-butyloxycarbonyl)amino]-1-[2H₅]benzyl-3-(benzyloxy)propan-2S-ol

: N-{3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-[2H₅]phenylmethyl-2-hydroxy-propyl}-2-[2-(3-fluorobenzylamino)-acetylamino]-3,3-dimethyl-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / hydrogen / Pd/C / ethyl acetate / 18 h

2.1: 1-bromocarbonyl-1-methylethyl acetate / CHCl₃ / 3 h / 20 °C

2.2: 73 percent / NaOMe / tetrahydrofuran / 4 h / 20 °C

3.1: 100 percent / propan-2-ol / 4 h / 86 °C

4.1: 885.8 mg / K₂CO₃ / isopropyl acetate; H₂O / 30 h / 56 °C

5.1: 80 percent / isopropyl acetate / 0.5 h / 85 °C

6.1: 1-hydroxybenzotriazole hydrate; 4-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide

6.2: dimethylformamide

6.3: 84 percent / methanesulfonic acid / isopropyl acetate / 0.5 h / 85 °C

7.1: 91 percent / 1-hydroxybenzotriazole hydrate; 4-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide

8.1: hydrogen / Pd/C / methanol / 3 h / 20 °C

8.2: 61 percent / trifluoroacetic acid; triethylsilane / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; acetoxyisobutyryl bromide; hydrogen; potassium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; chloroform; Isopropyl acetate; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/jlcr.870