(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

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Chemical Name:(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole
CAS No.:926659-97-4
Molecular Formula:C₂₉H₃₁FN₂OSi
Molecular Weight:470.662
Hs Code.:

Synonyms:(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

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Chemical Property of (S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

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Technology Process of (S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

There total 11 articles about (S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 926659-97-4
(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 2 h / 20 °C

2: Lawesson's reagent / tetrahydrofuran / 2 h / 20 °C

3: CH₂Cl₂ / 5 h / 20 °C

4: NH₄Cl / methanol / 3.5 h / 50 °C

5: ethyl acetate / 16 h / 20 °C

6: HBr; AcOH / aq. ethanol / 5.5 h / Heating

With Lawessons reagent; 1H-imidazole; hydrogen bromide; ammonium chloride; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.07.076

Reference yield:

: 926659-96-3
(S)-1-((1-(tert-butyldiphenylsilyloxy))but-3-en-2-yl)-4-(4-fluorophenyl)-1H-imidazole

: 926659-97-4
(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

: (R)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

Guidance literature:: With magnesium bromide; tricyclohexylphosphine; [RhCl(coe)2]2; In toluene; at 180 ℃; for 5.5h; Title compound not separated from byproducts;
DOI:10.1021/ja0676004

Reference yield:

: 926660-08-4
(S)-2-[4-(4-fluorophenyl)-imidazolyl]-but-3-enol

: 926659-97-4
(S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / iPr₂NEt; 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 20 °C

2: tricyclohexylphosphine; MgBr₂ / [RhCl(coe)2]2 / toluene / 5.5 h / 180 °C

With dmap; N-ethyl-N,N-diisopropylamine; magnesium bromide; tricyclohexylphosphine; [RhCl(coe)2]2; In dichloromethane; toluene;
DOI:10.1021/ja0676004