(1aS,8R,8aR,8bS)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

Base Information

Chemical Name:(1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole
CAS No.:129077-34-5
Molecular Formula:C₄₁H₅₀N₂O₆SSi
Molecular Weight:727.009
Hs Code.:

(1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

Synonyms:(1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

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Chemical Property of (1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

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Technology Process of (1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

There total 2 articles about (1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 129056-07-1
(1aS*,8R*,9aS*)-4,7-dibenzyloxy-6-methoxy-5,8-dimethyl-9-oxo-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

: 129077-34-5
(1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

Guidance literature:: With triethylamine; In dichloromethane; at -78 - 25 ℃;
DOI:10.1039/c39900000468

Reference yield:

: 129077-33-4
(1aS*,8R*,9R*,9aS*)-4,7-dibenzyloxy-9-hydroxy-6-methoxy-5,8-dimethyl-1,3-bis(p-toluenesulfonyl)-1a,2,3,8,9,9a-hexahydro-1H-azirino<2,3-c><1>benzazocine

: 129077-34-5
(1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / PCC, molecular sieves 4A / CH₂Cl₂ / 35 h / Ambient temperature

2: 100 percent / Et₃N / CH₂Cl₂ / 0.17 h / Ambient temperature

With 4 A molecular sieve; triethylamine; pyridinium chlorochromate; In dichloromethane;

Reference yield:

: 129077-34-5
(1aS*,8R*,8aR*,8bS*)-4,7-dibenzyloxy-8a-tert-butyldimethylsiloxy-6-methoxy-5,8-dimethyl-1-p-toluenesulfonyl-1,1a,2,8,8a,8b-hexahydroazirino<2',3':3,4>pyrrolo<1,2-a>indole

: C₂₇H₃₈N₂O₆SSi

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; for 0.166667h;
DOI:10.1039/c39900000468