methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate

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Chemical Name:methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate
CAS No.:701981-91-1
Molecular Formula:C₃₀H₄₃N₃O₆
Molecular Weight:541.688
Hs Code.:

Synonyms:methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate

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Chemical Property of methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate

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Technology Process of methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate

There total 8 articles about methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 30293-88-0,56753-77-6,39570-63-3
N-carbonyl-L-leucine methyl ester

: 162536-41-6
(2R,3S)-1-(benzylamino)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol

: 701981-91-1
methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 6.5h;
DOI:10.1021/jacs.9b13405

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 701981-91-1
methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃ / CH₂Cl₂; toluene / 0.5 h

2: CH₂Cl₂ / 6 h

With sodium hydrogencarbonate; In dichloromethane; toluene;
DOI:10.1021/jm049566e