5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Base Information

• Chemical Name: 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
• CAS No.: 343974-64-1
• Molecular Formula: C₁₇H₁₉N₅O
• Molecular Weight: 309.371

Synonyms:5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Chemical Property of 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

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Technology Process of 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

There total 2 articles about 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-[4-amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester (197525-84-1) → 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (343974-64-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1016/S0960-894X(01)00080-4

Reference yield:

5-(3-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine (194787-34-3) → 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (343974-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / K₂CO₃; 18-crown-6 / dimethylformamide / 55 °C

2: 70 percent / 4 N HCl / diethyl ether / 20 °C

With hydrogenchloride; 18-crown-6 ether; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00080-4

Reference yield: 70.0%

bromoacetic acid methyl ester (96-32-2) + 5-(3-methoxy-phenyl)-7-pyrrolidin-3-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (343974-64-1) → {3-[4-amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidin-1-yl}-acetic acid methyl ester (343974-65-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00080-4

upstream raw materials:

3-[4-amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

5-(3-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine

Downstream raw materials:

{3-[4-amino-5-(3-methoxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-pyrrolidin-1-yl}-acetic acid methyl ester

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