2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran

Base Information

• Chemical Name: 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran
• CAS No.: 138152-09-7
• Molecular Formula: C₁₆H₂₈O
• Molecular Weight: 236.398
• Mol file: 138152-09-7.mol

Synonyms:2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran

Chemical Property of 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran

There total 9 articles about 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(E)-4-Methyl-6-(2',6',6'-trimethyl-1'-cyclohexenyl)hex-3-en-1-ol (110202-07-8) → 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran (138152-09-7)

Guidance literature:

With Fe-MMT; In acetonitrile; at 80 ℃; for 21h; regioselective reaction; Schlenk technique;

DOI:10.1039/c4gc01990c

Reference yield:

(E)-4-Methyl-6-(2',6',6'-trimethyl-1'-cyclohexenyl)hex-3-en-1-ol (110202-07-8) → (+/-)-5β,8α,9β-Ambrox (3738-00-9,6790-58-5,67844-43-3,68365-88-8,68365-89-9,100679-85-4,105561-31-7,108945-29-5,119818-38-1,122566-15-8,122566-16-9,122566-18-1,124578-52-5,131831-61-3,131831-62-4,131831-63-5,133907-53-6,138283-79-1,138283-80-4,145164-17-6) + (±)-ambrox (3738-00-9,6790-58-5,67844-43-3,68365-88-8,68365-89-9,100679-85-4,105561-31-7,108945-29-5,119818-38-1,122566-15-8,122566-16-9,122566-18-1,124578-52-5,131831-61-3,131831-62-4,131831-63-5,133907-53-6,138283-79-1,138283-80-4,145164-17-6) + 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran (138152-09-7) + (3aRS,5aSR,9aSR,9bSR)-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan (3738-00-9,6790-58-5,67844-43-3,68365-88-8,68365-89-9,100679-85-4,105561-31-7,108945-29-5,119818-38-1,122566-15-8,122566-16-9,122566-18-1,124578-52-5,131831-61-3,131831-62-4,131831-63-5,133907-53-6,138283-79-1,138283-80-4,145164-17-6)

Guidance literature:

With fluorosulphonic acid; In various solvent(s); at -90 ℃; Yield given. Further byproducts given;

DOI:10.1021/jo00029a031

Reference yield:

(E)-4-Methyl-6-(2',2'-dimethyl-6'-methylidenecyclohexyl)hex-3-en-1-ol (133859-01-5) → (+/-)-5β-Ambrox (3738-00-9,6790-58-5,67844-43-3,68365-88-8,68365-89-9,100679-85-4,105561-31-7,108945-29-5,119818-38-1,122566-15-8,122566-16-9,122566-18-1,124578-52-5,131831-61-3,131831-62-4,131831-63-5,133907-53-6,138283-79-1,138283-80-4,145164-17-6) + (+/-)-5β,8α,9β-Ambrox (3738-00-9,6790-58-5,67844-43-3,68365-88-8,68365-89-9,100679-85-4,105561-31-7,108945-29-5,119818-38-1,122566-15-8,122566-16-9,122566-18-1,124578-52-5,131831-61-3,131831-62-4,131831-63-5,133907-53-6,138283-79-1,138283-80-4,145164-17-6) + (±)-ambrox (3738-00-9,6790-58-5,67844-43-3,68365-88-8,68365-89-9,100679-85-4,105561-31-7,108945-29-5,119818-38-1,122566-15-8,122566-16-9,122566-18-1,124578-52-5,131831-61-3,131831-62-4,131831-63-5,133907-53-6,138283-79-1,138283-80-4,145164-17-6) + 2-Methyl-2-<2'-(2'',6'',6''-trimethylcyclohex-1''-enyl)ethyl>tetrahydrofuran (138152-09-7)

Guidance literature:

With fluorosulphonic acid; In various solvent(s); at -90 ℃; Yield given. Further byproducts given;

DOI:10.1021/jo00029a031

upstream raw materials:

(Z)-4-Methyl-6-(2',6',6'-trimethyl-1'-cyclohexenyl)hex-3-en-1-ol

(E)-4-Methyl-6-(2',6',6'-trimethyl-1'-cyclohexenyl)hex-3-en-1-ol

(Z)-4-Methyl-6-(2',2'-dimethyl-6'-methylidenecyclohexyl)hex-3-en-1-ol

(E)-4-Methyl-6-(2',2'-dimethyl-6'-methylidenecyclohexyl)hex-3-en-1-ol