Acetyl-leucyl-leucyl-norleucine-aldehyde

Base Information

• Chemical Name: Acetyl-leucyl-leucyl-norleucine-aldehyde
• CAS No.: 110044-82-1
• Molecular Formula: C₂₀H₃₇N₃O₄
• Molecular Weight: 383.531
• Hs Code.: 29241900
• Mol file: 110044-82-1.mol

Synonyms:Ac-Leu-Leu-Nle-al;acetyl-leucyl-leucyl-norleucinal;acetyl-leucyl-leucyl-norleucine-aldehyde;acetylleucyl-leucyl-norleucinal;ALLN peptide;ALLNal;calpain inhibitor I;CPI(1);LLnL peptide;N-Ac-Leu-Leu-norleucinal;N-acetyl-leucyl-leucyl-norleucinal

Chemical Property of Acetyl-leucyl-leucyl-norleucine-aldehyde

Chemical Property:

• Vapor Pressure: 6.87E-16mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 632.2°Cat760mmHg
• PKA: 13.53±0.46(Predicted)
• Flash Point: 192.9°C
• PSA: 104.37000
• Density: 1.02g/cm³
• LogP: 3.11470
• Storage Temp.: −20°C
• Solubility.: DMSO: soluble
• Water Solubility.: Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
• XLogP3: 3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 13
• Exact Mass: 383.27840667
• Heavy Atom Count: 27
• Complexity: 492

Purity/Quality:

99% ^*data from raw suppliers

MG 101 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C
• Isomeric SMILES: CCCC[C@@H](C=O)NC(=O)C(CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C
• Description: ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1?Inhibits cell cycle progression at G1/S?and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2?Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3?Blocks AIF-mediated necroptosis.4?Cell permeable.
• Uses: Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation. It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Calpain inhibitor I inhibits calpain, which activates myosin light chain kinase and protein kinase C by partial proteolysis. The inhibitor should be membrane permeable due to low molecular weight and lack of charged residues.Calpain Inhibitor I is used for western blotting methods.

Technology Process of Acetyl-leucyl-leucyl-norleucine-aldehyde

There total 2 articles about Acetyl-leucyl-leucyl-norleucine-aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal (110044-82-1)

Guidance literature:

Reference yield:

→ ALLN (110044-82-1)

Guidance literature:

Reference yield:

N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal (110044-82-1) → C40H65N9O8

Guidance literature:

Multi-step reaction with 2 steps

1.1: Oxone / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: N,N-dimethyl-formamide

2.2: 2 h / 20 °C

With Oxone; In N,N-dimethyl-formamide;

Refernces

• 1、 -. "Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient". . . Retrieved 2008/06/13.