(2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

Base Information

Chemical Name:(2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid
CAS No.:130190-48-6
Molecular Formula:C₃₀H₃₈N₂O₁₆S₂
Molecular Weight:746.768
Hs Code.:

Synonyms:(2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

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Chemical Property of (2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

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Technology Process of (2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

There total 7 articles about (2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 130190-44-2
(2R,3R,11R,12R)-N,N,N',N',N'',N'',N''',N'''-Octamethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxamide

: 130190-48-6
(2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

Guidance literature:: With hydrogenchloride; In methanol; water; for 4h; Heating;

Reference yield:

: 100190-95-2
(2R,3R)-N,N,N',N'-Tetramethyl-2,3-bis(2-hydroxyethyl)succinamide

: 130190-48-6
(2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) Cs₂CO₃ / 1.) DMF, 1,5 h, room temperature, 2.) DMF, 20 h, room temperature

3: 71 percent / conc. HCl / methanol; H₂O / 4 h / Heating

With hydrogenchloride; caesium carbonate; triethylamine; In methanol; dichloromethane; water;

Reference yield:

: 130190-42-0
(2R,3R)-N,N,N',N'-Tetramethyl-2,3-bis(2-aminoethyl)succinamide

: 130190-48-6
(2R,3R,11R,12R)-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3,11,12-tetracarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / K₂CO₃ / H₂O / 4 h / 50 °C

2: 1.) Cs₂CO₃ / 1.) DMF, 1,5 h, room temperature, 2.) DMF, 20 h, room temperature

3: 71 percent / conc. HCl / methanol; H₂O / 4 h / Heating

With hydrogenchloride; potassium carbonate; caesium carbonate; In methanol; water;