1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

Base Information

Chemical Name:1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one
CAS No.:1161439-78-6
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

Synonyms:1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

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Chemical Property of 1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

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Technology Process of 1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

There total 4 articles about 1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: ethyl 2-(N-(tert-butoxycarbonyl)-2-(4'-methoxyphenyl)acetamido)acetate

: 1161439-78-6
1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 40 ℃; for 6h; Inert atmosphere;
DOI:10.1021/jo501185f

Reference yield: 28.0%

: 623-12-1
4-chloromethoxybenzene

: 182352-48-3
2-oxo-4-pent-4-enyloxy-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 1161439-78-6
1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: With palladium diacetate; potassium carbonate; tert-butyl XPhos; In tetrahydrofuran; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo900799y

Reference yield:

: 349093-73-8
ethyl 2-((4'-methoxyphenyl)acetamido)acetate

: 1161439-78-6
1-(tert-butoxycarbonyl)-4-hydroxy-3-(4′-methoxyphenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 2 h / 20 - 40 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 6 h / 0 - 40 °C / Inert atmosphere

With dmap; potassium tert-butylate; In tetrahydrofuran; 2: |Dieckmann Condensation;
DOI:10.1021/jo501185f