N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
CAS No.:1092392-30-7
Molecular Formula:C₂₃H₂₁N₅O₃S
Molecular Weight:447.517
Hs Code.:

Synonyms:N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

There total 5 articles about N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.1%

: 55458-67-8
1,3-dimethyl-1H-pyrazole-5-carbonyl chloride

: 1123580-24-4
N-[6-(3-aminophenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide

: 1092392-30-7
N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield: 5.1%

: 55458-67-8
1,3-dimethyl-1H-pyrazole-5-carbonyl chloride

: 1092394-82-5
N-[6-(3-nitrophenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide

: 1092392-30-7
N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: N-[6-(3-nitrophenoxy)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide; With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 5h;

With iron; calcium chloride; In ethanol; water; for 2h;

1,3-dimethyl-1H-pyrazole-5-carbonyl chloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 865861-21-8
N-(6-hydroxy-1,3-benzothiazol-2-yl)cyclopropanecarboxamide

: 1092392-30-7
N-[3-({2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 150 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 5 h / 20 °C

2.2: 2 h

2.3: 3 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.042