2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Base Information

Chemical Name:2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
CAS No.:1092523-24-4
Molecular Formula:C₁₂H₁₃ClN₄O₂
Molecular Weight:280.714
Hs Code.:
Mol file:1092523-24-4.mol

Synonyms:2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Suppliers and Price of 2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-?Amino-?7-?chloro-?1-?ethyl-?N-?methyl-?4-?oxo-?1,?4-?dihydro-?1,?8-?naphthyridine-?3-?carboxamide
50mg
$ 150.00

Medical Isotopes, Inc.
2-Amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
1 g
$ 2875.00

Medical Isotopes, Inc.
2-Amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
50 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of 2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Chemical Property:

Melting Point:274-276oC (dec.)
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly, Heated), Ethyl Acetate (Slightly, Heated)

Purity/Quality:: 2-?Amino-?7-?chloro-?1-?ethyl-?N-?methyl-?4-?oxo-?1,?4-?dihydro-?1,?8-?naphthyridine-?3-?carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-Amino-7-chloro-1-ethyl-1,4-dihydro-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide is an intermediate in the synthesis of SAR131675 (S139510), is a potent and selective VEGFR-3 inhibitor.

Technology Process of 2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

There total 5 articles about 2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1092523-22-2
6-chloro-2-(ethylamino)pyridine-3-carbonyl fluoride

: 6330-25-2
N-methyl-2-cyanoacetamide

: 1092523-24-4
2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: N-methyl-2-cyanoacetamide; With hydrogen; sodium hydride; In water; N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.166667h;

6-chloro-2-(ethylamino)pyridine-3-carbonyl fluoride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

Reference yield: 57.0%

: 1092523-23-3
3-[6-chloro-2-(ethylamino)pyridin-3-yl]-2-cyano-3-hydroxy-N-methylprop-2-enamide

: 1092523-24-4
2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: In butan-1-ol; at 110 ℃; for 48h;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1092523-24-4
2-amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water / 10 h / 50 °C

2.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 0 - 20 °C

4.1: butan-1-ol / 48 h / 110 °C

With pyridine; trifluoro-[1,3,5]triazine; sodium hydride; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil; butan-1-ol;