(E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate

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Chemical Name:(E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate
CAS No.:1610539-73-5
Molecular Formula:C₁₈H₁₃F₃N₂O₃
Molecular Weight:362.308
Hs Code.:

Synonyms:(E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate

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Chemical Property of (E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate

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Technology Process of (E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate

There total 2 articles about (E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1285695-08-0
N-benzyl-5-(trifluoromethyl)picolinamide

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1610539-73-5
(E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate

Guidance literature:: With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; In para-xylene; at 140 ℃; for 16h; stereoselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1039/c4cc02322f

Reference yield:

: 100-46-9
benzylamine

: 80194-69-0
5-(trifluoromethyl)picolinic acid

: 1610539-73-5
(E)-methyl 2-(6-benzyl-7-oxo-3-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-ylidene)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; silver hexafluoroantimonate / para-xylene / 16 h / 140 °C / Sealed tube; Inert atmosphere

With silver hexafluoroantimonate; oxalyl dichloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; N,N-dimethyl-formamide; In dichloromethane; para-xylene;
DOI:10.1039/c4cc02322f