2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

Base Information

Chemical Name:2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol
CAS No.:1616363-90-6
Molecular Formula:C₁₈H₂₄ClN₃OS
Molecular Weight:365.927
Hs Code.:

Synonyms:2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

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Chemical Property of 2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

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Technology Process of 2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

There total 6 articles about 2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-2-((4S,6S,7R)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

: 1616363-90-6
2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

Guidance literature:: With diethylamine; In n-heptane; Resolution of racemate;

Reference yield:

: 539-88-8
4-oxopentanoic acid ethyl ester

: 1616363-90-6
2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / diethyl ether / 3 h / 0 °C

2.1: sodium hydrogen sulfide / water / 3 h / 0 °C

3.1: toluene-4-sulfonic acid / acetonitrile / 18 h / 90 °C

4.1: sodium tetrahydroborate / methanol / 16 h / 0 - 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 4.5 h / 0 - 20 °C

5.2: 0.5 h / 0 °C

6.1: diethylamine / n-heptane / Resolution of racemate

With sodium hydrogen sulfide; sodium tetrahydroborate; bromine; diisobutylaluminium hydride; toluene-4-sulfonic acid; diethylamine; In tetrahydrofuran; methanol; diethyl ether; n-heptane; water; acetonitrile;

Reference yield:

: 54260-84-3
ethyl 3-bromo-4-oxopentanoate

: 1616363-90-6
2-((4R,6R,7S)-4-(4-chloro-2-methylphenyl)-1,3,7-trimethyl-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-6-yl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogen sulfide / water / 3 h / 0 °C

2.1: toluene-4-sulfonic acid / acetonitrile / 18 h / 90 °C

3.1: sodium tetrahydroborate / methanol / 16 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 4.5 h / 0 - 20 °C

4.2: 0.5 h / 0 °C

5.1: diethylamine / n-heptane / Resolution of racemate

With sodium hydrogen sulfide; sodium tetrahydroborate; diisobutylaluminium hydride; toluene-4-sulfonic acid; diethylamine; In tetrahydrofuran; methanol; n-heptane; water; acetonitrile;