(S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Base Information

Chemical Name:(S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate
CAS No.:1204671-16-8
Molecular Formula:C₂HF₃O₂*C₁₇H₁₇F₂NO
Molecular Weight:403.349
Hs Code.:

Synonyms:(S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

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Chemical Property of (S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

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Technology Process of (S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

There total 6 articles about (S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204677-42-8
(S)-3-((R)-hydroxyphenylmethyl)pyrrolidine-1-carboxylic acid t-butyl ester

: 2265-93-2
2,4-difluoro-1-iodobenzene

: 1204671-16-8
(S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In toluene; at 105 ℃; for 48h;

Reference yield:

: 1204671-15-7
(S)-3-[(R)-(2,4-Difluorophenoxy)phenylmethyl]pyrrolidine

: 76-05-1
trifluoroacetic acid

: 1204671-16-8
(S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: In water; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

: 199174-24-8
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1204671-16-8
(S)-3-[(R)-(2,4-difluorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 0 °C

2: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 48 h / 105 °C

4: hydrogenchloride / ethanol

5: water; acetonitrile

With hydrogenchloride; sodium hypochlorite; copper(l) iodide; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; caesium carbonate; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.061