2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Base Information

Chemical Name:2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride
CAS No.:1620955-84-1
Molecular Formula:C₂₇H₂₅N₅O₄*ClH
Molecular Weight:519.988
Hs Code.:

Synonyms:2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

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Chemical Property of 2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

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Technology Process of 2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

There total 10 articles about 2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620955-83-0
C₃₂H₃₃N₅O₆

: 1620955-84-1
2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 ℃; for 4h; Inert atmosphere;

Reference yield:

: 191338-94-0
ethyl {4-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}(oxo)acetate

: 1620955-84-1
2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / ethanol / 2 h / Reflux

1.2: 16 h

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C

3.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

3.2: 8 h / Reflux

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1620955-84-1
2-(4'-(2-morpholino-2-oxoethoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridine-4-carbohydrazide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetone / 16 h / 0 - 20 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 0 - 20 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

5.1: caesium carbonate / ethanol; water; 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

5.2: 8 h / Reflux

6.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 0 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; water; potassium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;