1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

Base Information

Chemical Name:1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea
CAS No.:849217-41-0
Molecular Formula:C₂₅H₂₂FN₅O₃S
Molecular Weight:491.546
Hs Code.:

Synonyms:1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

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Chemical Property of 1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

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Technology Process of 1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

There total 5 articles about 1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 849217-40-9
N-(6,7-dimethoxy-quinazolin-4-yl)-2-fluoro-benzene-1,4-diamine

: 29313-32-4
2-phenylacetyl isothiocyanate

: 849217-41-0
1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

Guidance literature:: In methanol; ethanol; toluene; at 20 ℃;

Reference yield:

: 849217-39-6
(6,7-dimethoxy-quinazolin-4-yl)-(2-fluoro-4-nitro-phenyl)-amine

: 849217-41-0
1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol; N,N-dimethyl-formamide / 3 h / 2068.65 Torr

2: methanol; ethanol; toluene / 20 °C

With hydrogen; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 849217-41-0
1-[4-(6,7-dimethoxy-quinazolin-4-ylamino)-3-fluoro-phenyl]-3-phenylacetyl-thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetonitrile / Heating / reflux

2: hydrogen / palladium 10% on activated carbon / methanol; N,N-dimethyl-formamide / 3 h / 2068.65 Torr

3: methanol; ethanol; toluene / 20 °C

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;