1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

Base Information

Chemical Name:1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate
CAS No.:1297136-78-7
Molecular Formula:C₇H₈F₃N₂O*C₉H₁₁O₃S
Molecular Weight:392.399
Hs Code.:

Synonyms:1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

Suppliers and Price of 1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

There total 10 articles about 1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1065103-97-0
4-(methyloxy)-2-(trifluoromethyl)pyridine

: 36016-40-7
mesitylenesulfonylhydroxylamine

: 1297136-78-7
1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

Guidance literature:: In dichloromethane; at 20 ℃;

Reference yield:

: 1297137-87-1
dimethyl 5-(ethyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2,3-dicarboxylate

: 1297136-78-7
1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 2 h / 90 °C

1.2: 90 °C

2.1: sulfuric acid / Reflux

2.2: 90 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4.5 h / 90 °C / Inert atmosphere

5.1: 3-(1-{[3,4-dichloro-5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-yl]carbonyl}-4-piperidinyl)-1,3-oxazolidin-2-one / N,N-dimethyl-formamide / 1 h / 60 °C

6.1: sodium hydroxide / methanol / 4 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

9.1: dichloromethane / 20 °C

With potassium phosphate; sulfuric acid; 3-(1-{[3,4-dichloro-5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-yl]carbonyl}-4-piperidinyl)-1,3-oxazolidin-2-one; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1297136-86-7
5-hydroxy-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid

: 1297136-78-7
1-amino-4-(methyloxy)-2-(triftuoromethyl)pyridinium 2,4,6-trimethylbenzenesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / Reflux

1.2: 90 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4.5 h / 90 °C / Inert atmosphere

4.1: 3-(1-{[3,4-dichloro-5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-yl]carbonyl}-4-piperidinyl)-1,3-oxazolidin-2-one / N,N-dimethyl-formamide / 1 h / 60 °C

5.1: sodium hydroxide / methanol / 4 h / 50 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 65 °C

8.1: dichloromethane / 20 °C

With potassium phosphate; 3-(1-{[3,4-dichloro-5-(methyloxy)-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-yl]carbonyl}-4-piperidinyl)-1,3-oxazolidin-2-one; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;