(E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile

Base Information

• Chemical Name: (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile
• CAS No.: 133149-50-5
• Molecular Formula: C₁₇H₁₁N₃O₂
• Molecular Weight: 289.293

Synonyms:(E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile

Chemical Property of (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile

There total 5 articles about (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + 2-(4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile (30750-23-3) → (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile (133149-50-5)

Guidance literature:

With sodium acetate; In acetic acid; for 2h; Heating;

Reference yield: 75.0%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + 2-cyano-2-(4-hydroxybenzylidene)thioacetamide (133149-51-6) → (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile (133149-50-5)

Guidance literature:

In neat (no solvent); at 130 - 135 ℃;

Reference yield: 62.0%

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + (Z)-2-Cyano-3-(4-hydroxy-phenyl)-thioacrylimidic acid methyl ester (133149-55-0) → (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile (133149-50-5)

Guidance literature:

In ethanol; for 5h; Heating;

upstream raw materials:

4-hydroxy-benzaldehyde

2-(4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile

anthranilic acid

2-cyano-2-(4-hydroxybenzylidene)thioacetamide

Downstream raw materials:

9-Amino-8-benzoyl-7-(4-hydroxy-phenyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carbonitrile

7-(4-Hydroxy-phenyl)-9,11-dioxo-8,11-dihydro-9H-pyrido[2,1-b]quinazoline-6,8-dicarbonitrile

9-Amino-7-(4-hydroxy-phenyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-6,8-dicarbonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133149-50-5 (E)-3-(4-Hydroxy-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send