3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene

Base Information

Chemical Name:3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene
CAS No.:1354930-54-3
Molecular Formula:C₂₂H₁₉ClN₂O
Molecular Weight:362.859
Hs Code.:

Synonyms:3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene

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Chemical Property of 3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene

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Technology Process of 3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene

There total 2 articles about 3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.5%

: 1354930-45-2
3-(3-chlorophenylethynyl)-8-oxo-1-oxa-2-azaspiro[4.5]dec-2-ene

: 38700-15-1
triphenyl-(2-pyridylmethyl)phosphonium chloride

: 1354930-54-3
3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene

: 1354931-45-5
3-(3-chlorophenylethynyl)-8-hydroxy-8-(2-pyridylmethyl)-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: triphenyl-(2-pyridylmethyl)phosphonium chloride; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.5h; Inert atmosphere;

3-(3-chlorophenylethynyl)-8-oxo-1-oxa-2-azaspiro[4.5]dec-2-ene; In tetrahydrofuran; at -20 - 65 ℃; for 3h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1354930-44-1
3-(3-chlorophenylethynyl)-1,9,12-trioxa-2-azadispiro[4.2.4.2]tetradec-2-ene

: 1354930-54-3
3-(3-chlorophenylethynyl)-8-(2-pyridylmethylene)-1-oxa-2-azaspiro[4.5]dec-2-ene

: 1354931-45-5
3-(3-chlorophenylethynyl)-8-hydroxy-8-(2-pyridylmethyl)-1-oxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; water / 4 h / 0 - 4 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

2.2: 3 h / -20 - 65 °C / Inert atmosphere

2.3: 20 °C

With water; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran;