C₆₅H₁₀₅N₅O₁₅Si

Base Information

• Chemical Name: C₆₅H₁₀₅N₅O₁₅Si
• CAS No.: 220440-09-5
• Molecular Formula: C₆₅H₁₀₅N₅O₁₅Si
• Molecular Weight: 1224.66
• Mol file: 220440-09-5.mol

Synonyms:C₆₅H₁₀₅N₅O₁₅Si

Chemical Property of C₆₅H₁₀₅N₅O₁₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₅H₁₀₅N₅O₁₅Si

There total 9 articles about C₆₅H₁₀₅N₅O₁₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C71H119N5O15Si2 (383910-51-8) → C65H105N5O15Si (220440-09-5)

Guidance literature:

With acetic acid; In tetrahydrofuran; for 16h;

DOI:10.1021/jo0105991

Reference yield:

L-Tic-OH (74163-81-8) → C65H105N5O15Si (220440-09-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 97 percent / NaHCO₃ / H₂O / 1.5 h / 20 °C

2.1: 89 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

3.1: 86 percent / H₂ / Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr

4.1: BOP-Cl; NMM / CH₂Cl₂ / 0.5 h / -15 °C

4.2: 60 percent / NMM / CH₂Cl₂ / 6 h / 0 °C

5.1: 100 percent / MgBr₂*Et₂O / CH₂Cl₂ / 4.5 h / -20 - 0 °C

6.1: 47 percent / NMM; isopropenyl chloroformate / CH₂Cl₂ / 4 h / -15 - 20 °C

7.1: 83 percent / aq. AcOH / tetrahydrofuran / 16 h

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydrogencarbonate; acetic acid; triethylamine; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;

DOI:10.1021/jo0105991

Reference yield:

(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester (79261-58-8) → C65H105N5O15Si (220440-09-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 89 percent / Et₃N; DMAP; isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

2.1: 86 percent / H₂ / Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr

3.1: BOP-Cl; NMM / CH₂Cl₂ / 0.5 h / -15 °C

3.2: 60 percent / NMM / CH₂Cl₂ / 6 h / 0 °C

4.1: 100 percent / MgBr₂*Et₂O / CH₂Cl₂ / 4.5 h / -20 - 0 °C

5.1: 47 percent / NMM; isopropenyl chloroformate / CH₂Cl₂ / 4 h / -15 - 20 °C

6.1: 83 percent / aq. AcOH / tetrahydrofuran / 16 h

With 4-methyl-morpholine; dmap; Isopropenyl chloroformate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; acetic acid; triethylamine; magnesium bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

DOI:10.1021/jo0105991

upstream raw materials:

(3S,4R,5S)-4-Amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid (1S,2S,3R)-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-2-methoxymethoxy-3-methyl-butyl ester

Cbz-leucylpropyl-L-(3-carboxy-1,2,3,4-tetrahydroisoquinoline)-O-Boc-threonine

C₇₁H₁₁₉N₅O₁₅Si₂

((benzyloxy)carbonyl)-L-leucyl-L-proline

Downstream raw materials:

C₇₁H₁₀₂F₅N₅O₁₆Si

C₆₅H₁₀₃O₁₅N₅SiO