(2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

Base Information

Chemical Name:(2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid
CAS No.:119593-43-0
Molecular Formula:C₁₂H₁₅NO₅S
Molecular Weight:285.321
Hs Code.:

Synonyms:(2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

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Chemical Property of (2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

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Technology Process of (2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

There total 6 articles about (2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119593-75-8
(2S,3R)-3-hydroxy-2-(hydroxymethyl)-1-(phenylsulfonyl)piperidine

: 119593-43-0
(2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

Guidance literature:: With oxygen; platinum(IV) oxide; In water; ethyl acetate; isopropyl alcohol; at 60 ℃; for 18h; Yield given;
DOI:10.1021/jo00269a023

Reference yield:

: 119593-39-4,119716-99-3,151213-75-1
(4R,5S)-5-<(phenylsulfonyl)amino>-2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxane

: 119593-43-0
(2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: calcined K₂CO₃ / methanol / 4 h / Ambient temperature

3: 100 percent / 1 M aq. HCl / methanol / 1 h / Ambient temperature

4: O₂ / PtO₂ / H₂O; ethyl acetate; propan-2-ol / 18 h / 60 °C

With hydrogenchloride; calcined K₂CO₃; oxygen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jo00269a023

Reference yield:

: 119593-28-1
(4R,5S)-5-<(phenylsulfonyl)amino>-4-allyl-2,2-dimethyl-1,3-dioxane

: 119593-43-0
(2R,3R)-N-(phenylsulfonyl)-3-hydroxypipecolic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) BH₃*THF, 2.) 30percent H₂O₂, 3 M NaOH / 1.) THF, RT, 1 h, 2.) THF, 45 deg C, 0.5 h

2: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: calcined K₂CO₃ / methanol / 4 h / Ambient temperature

4: 100 percent / 1 M aq. HCl / methanol / 1 h / Ambient temperature

5: O₂ / PtO₂ / H₂O; ethyl acetate; propan-2-ol / 18 h / 60 °C

With hydrogenchloride; sodium hydroxide; borane-THF; calcined K₂CO₃; dihydrogen peroxide; oxygen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jo00269a023