(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

Base Information

Chemical Name:(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester
CAS No.:254102-29-9
Molecular Formula:C₁₄H₁₇NO₃
Molecular Weight:247.294
Hs Code.:

Synonyms:(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

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Chemical Property of (R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

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Technology Process of (R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

There total 1 articles about (R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 54373-50-1
O-ethoxycarbonyl-3,5-dimethyl-4-chloromethylphenol

: 105-56-6
ethyl 2-cyanoacetate

: 254102-29-9
(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

Guidance literature:: With sodium ethanolate; In ethanol; for 2h; Heating;
DOI:10.1021/jm990165m

Reference yield: 85.0%

: 254102-29-9
(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

: 254102-30-2
(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 20 ℃; for 24h;
DOI:10.1021/jm990165m

Reference yield:

: 254102-29-9
(R,S)-2-cyano-3-(4-hydroxy-2',6'-dimethylphenyl)-propanoic acid ethyl ester

: 2-[2-aminomethyl-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NaOH / ethanol; H₂O / 24 h / 20 °C

2: 80 percent / 1-hydroxybenzotriazole; N,N'-dicyclohexylcarbodiimide / dimethylformamide / 27 h / 0 - 20 °C

3: 96 percent / TFA / 0.5 h / 20 °C

4: 98 percent / H₂; aq. HCl / PtO₂ / ethanol / 8 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; platinum(IV) oxide; In ethanol; water; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Condensation / 3: Hydrolysis / 4: Catalytic hydrogenation;
DOI:10.1021/jm990165m