5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

Base Information

Chemical Name:5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine
CAS No.:113306-21-1
Molecular Formula:C₁₆H₁₅N₃O
Molecular Weight:265.315
Hs Code.:

Synonyms:5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

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Chemical Property of 5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

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Technology Process of 5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

There total 6 articles about 5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 113306-20-0
5,6-dihydro-6-oxo-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

: 113306-21-1
5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 60 ℃; for 3h;
DOI:10.1002/jhet.5570240544

Reference yield:

: 113306-16-4
4-formyl-1-phenyl-5-(1-pyrryl)pyrazole

: 113306-21-1
5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / potassium carbonate / ethanol / 2 h / 70 °C

2: 97 percent / H₂ / 10percent palladium on charcoal / ethyl acetate / 6 h / 45 °C / 2585.7 Torr

3: 98 percent / aq. ethanol; aq. KOH / 1.25 h / Heating

4: 92 percent / polyphosphoric acid / 1 h / 90 °C

5: 79 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 60 °C

With lithium aluminium tetrahydride; PPA; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; potassium hydroxide; ethanol; ethyl acetate;
DOI:10.1002/jhet.5570240544

Reference yield:

: 113306-17-5
ethyl trans-3-<1-phenyl-5-(1-pyrryl)pyrazol-4-yl>propenoate

: 113306-21-1
5,6-dihydro-6-hydroxy-1-phenyl-1H,4H-pyrazolo<4,3-f>pyrrolo<1,2-a>azepine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / 10percent palladium on charcoal / ethyl acetate / 6 h / 45 °C / 2585.7 Torr

2: 98 percent / aq. ethanol; aq. KOH / 1.25 h / Heating

3: 92 percent / polyphosphoric acid / 1 h / 90 °C

4: 79 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 60 °C

With lithium aluminium tetrahydride; PPA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; potassium hydroxide; ethanol; ethyl acetate;
DOI:10.1002/jhet.5570240544