6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate

Base Information

• Chemical Name: 6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate
• CAS No.: 570376-60-2
• Molecular Formula: C₃₇H₄₆F₂O₈
• Molecular Weight: 656.764
• Mol file: 570376-60-2.mol

Synonyms:6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate

Chemical Property of 6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate

There total 1 articles about 6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-4'-hydroxybiphenyl (29558-77-8) → 6-(4-{4-[2,3-difluoro-4-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)phenyl]phenyl}phenoxy)hexanol monomethacrylate (570376-60-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / tetrabutylammonium iodide; K₂CO₃ / dimethylformamide / 24 h / 80 °C

2: 68 percent / Pd(PPh₃)4; aq. Na₂CO₃ / methanol; benzene / 2 h / Heating

3: 66 percent / K₂CO₃ / dimethylformamide / 16 h / 80 °C

4: 81 percent / Et₃N; 2,6-di-tert-butylphenol / CH₂Cl₂ / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butylphenol; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene; 2: Suzuki coupling;

DOI:10.1021/ja0549594

upstream raw materials:

4-bromo-4'-hydroxybiphenyl