N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

Base Information

Chemical Name:N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide
CAS No.:1393643-43-0
Molecular Formula:C₁₆H₂₅N₅O₃
Molecular Weight:335.406
Hs Code.:

Synonyms:N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

Chemical Property:

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Technology Process of N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

There total 5 articles about N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.4%

: 1393644-10-4
C₁₈H₂₈N₄O₃

: 1393643-43-0
N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In methanol; water; at 20 ℃;
DOI:10.3390/molecules16119178

Reference yield:

: 1019399-33-7
2-bromo-N-(4-dimethylamino-phenyl)-acetamide

: 1393643-43-0
N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydrogencarbonate / acetonitrile / Reflux

2: hydrogenchloride / ethanol / 16 h / 20 °C

3: potassium hydrogencarbonate / acetonitrile / Reflux

4: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; potassium hydrogencarbonate; sodium hydroxide; In methanol; ethanol; water; acetonitrile;
DOI:10.3390/molecules16119178

Reference yield:

: 1018633-29-8
C₁₄H₂₂N₄O

: 1393643-43-0
N-hydroxy-2-{4-[(4-dimethylaminophenylcarbamoyl)methyl]piperazin-1-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / acetonitrile / Reflux

2: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 20 °C

With hydroxylamine hydrochloride; potassium hydrogencarbonate; sodium hydroxide; In methanol; water; acetonitrile;
DOI:10.3390/molecules16119178