2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

Base Information

Chemical Name:2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile
CAS No.:1431978-54-9
Molecular Formula:C₁₉H₂₀F₃NS
Molecular Weight:351.436
Hs Code.:

Synonyms:2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

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Chemical Property of 2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

Chemical Property:

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Technology Process of 2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

There total 4 articles about 2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 392-83-6
o-trifluoromethylphenyl bromide

: 1431978-51-6
2-isopropyl-3-methyl-2-(thiophen-3-yl)butanenitrile

: 1431978-54-9
2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

Guidance literature:: With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; at 20 - 140 ℃; regioselective reaction; Schlenk technique;
DOI:10.1016/j.tet.2012.11.060

Reference yield:

: 616-44-4,84928-92-7
3-Methylthiophene

: 1431978-54-9
2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / Reflux

2.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C

3.2: 20 °C

4.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate; Trimethylacetic acid / 20 - 140 °C / Schlenk technique

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; lithium hexamethyldisilazane; Trimethylacetic acid; In tetrahydrofuran; tetrachloromethane; acetonitrile;
DOI:10.1016/j.tet.2012.11.060

Reference yield:

: 13781-53-8
(thiophen-3-yl)acetonitrile

: 1431978-54-9
2-isopropyl-3-methyl-2-(5-(2-(trifluoromethyl)phenyl)thiophen-3-yl)butanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; potassium carbonate; Trimethylacetic acid / 20 - 140 °C / Schlenk technique

With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; lithium hexamethyldisilazane; Trimethylacetic acid; In tetrahydrofuran;
DOI:10.1016/j.tet.2012.11.060