2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

Base Information

Chemical Name:2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid
CAS No.:1402393-83-2
Molecular Formula:C₄₁H₅₇F₃N₈O₁₄
Molecular Weight:942.944
Hs Code.:

2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

Synonyms:2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

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Chemical Property of 2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

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Technology Process of 2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

There total 5 articles about 2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1402393-82-1
di-tert-butyl 2,2'-(2-(2-(2-((2-(2-(4,10-bis(2-tert-butoxy-2-oxoethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetate

: 1402393-83-2
2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

Guidance literature:: di-tert-butyl 2,2'-(2-(2-(2-((2-(2-(4,10-bis(2-tert-butoxy-2-oxoethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 14h;

In water; for 2h;
DOI:10.1002/chem.201200737

Reference yield:

: 3792-04-9
2-chloro-N-[2-(trifluoromethyl)phenyl]acetamide

: 1402393-83-2
2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / 2068.65 Torr

4.1: 4-methyl-morpholine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 14 h / 20 °C

5.2: DOWEX 1X₈ anion exchange resin / 2 h

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; benzotriazol-1-ol; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201200737

Reference yield:

: 1402393-78-5
di-tert-butyl 2,2'-(4-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

: 1402393-83-2
2,2'-(2-(2-(2-((2-(2-(4,10-bis(carboxymethyl)-7-(2-oxo-2-(2-(trifluoromethyl)phenylamino)ethyl)-1,4,7,10-tetraazacyclododecan-1-yl)ethylamino)-2-oxoethyl)(carboxymethyl)amino)ethoxy)phenoxy)ethylazanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 8 h / 20 °C / 2068.65 Torr

3.1: 4-methyl-morpholine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 14 h / 20 °C

4.2: DOWEX 1X₈ anion exchange resin / 2 h

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.201200737