methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate

Base Information

• Chemical Name: methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate
• CAS No.: 942941-90-4
• Molecular Formula: C₁₉H₂₃ClN₂O₂S
• Molecular Weight: 378.923

Synonyms:methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate

Chemical Property of methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate

Chemical Property:

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Technology Process of methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate

There total 2 articles about methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-amine (942941-83-5) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate (942941-90-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate (942941-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.02.043

Reference yield: 78.0%

methyl 2-(4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-ylamino)acetate (942941-90-4) + N-tert-butyloxycarbonylsulfamoyl chloride (147000-89-3) → methyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)(5-(3-((N-(tert-butoxycarbonyl)sulfamoyl)(cyclohexyl)amino)phenyl)-4-chlorothiophen-3-yl)amino)acetate (942941-97-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

4-chloro-5-(3-(cyclohexylamino)phenyl)thiophen-3-amine

bromoacetic acid methyl ester

cyclohexanone

Downstream raw materials:

methyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)(5-(3-((N-(tert-butoxycarbonyl)sulfamoyl)(cyclohexyl)amino)phenyl)-4-chlorothiophen-3-yl)amino)acetate

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