Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Base Information

Chemical Name:Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester
CAS No.:850005-83-3
Molecular Formula:C₂₉H₃₉NO₄S₂Si
Molecular Weight:557.85
Hs Code.:

Synonyms:Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Suppliers and Price of Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

There total 5 articles about Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 850005-75-3
3-((1R)-1-hydroxy-3-((4S)-isopropyl-2-thioxothiazolidin-3-yl)-3-oxopropyl)benzyl benzoate

: 104410-90-4
tert-butyldimethylsilyl trifluoroacetate

: 850005-83-3
Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2005.01.062

Reference yield:

: 626-19-7
Isophthalaldehyde

: 850005-83-3
Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 63 percent / sodium borohydride / ethanol / 1 h / 20 °C

2.1: 87 percent / triethylamine / CH₂Cl₂ / 1 h / 20 °C

3.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / 2 h / -40 °C

3.2: 76 percent / CH₂Cl₂ / 0.5 h / -78 °C

4.1: 84 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2005.01.062

Reference yield:

: 52010-98-7
3-(hydroxymethyl)benzaldehyde

: 850005-83-3
Benzoic acid 3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-3-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-3-oxo-propyl]-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / triethylamine / CH₂Cl₂ / 1 h / 20 °C

2.1: titanium(IV) chloride; diisopropylethylamine / CH₂Cl₂ / 2 h / -40 °C

2.2: 76 percent / CH₂Cl₂ / 0.5 h / -78 °C

3.1: 84 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 20 °C

With 2,6-dimethylpyridine; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.tet.2005.01.062