16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester

Base Information

Chemical Name:16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester
CAS No.:73285-92-4
Molecular Formula:C₂₃H₃₆O₅S
Molecular Weight:424.602
Hs Code.:

Synonyms:BRN 5646154;16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester;73285-92-4;16-(Cyclohex-1-enylthio)-17,18,19,20-tetranorprostaglandin F2-alpha methyl ester;5-Heptenoic acid, 7-(2-(4-(1-cyclohexen-1-ylthio)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, methyl ester, (1R-(1-alpha(Z),2-beta(1E,3S*),3-alpha,5-alpha))-;C23H36O5S;C23-H36-O5-S;LS-74587

Suppliers and Price of 16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester

Chemical Property:

Vapor Pressure:9.89E-16mmHg at 25°C
Boiling Point:577.3°Cat760mmHg
Flash Point:302.9°C
PSA：112.29000
Density:1.17g/cm³
LogP:3.74210
XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:424.22834542
Heavy Atom Count:29
Complexity:586

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CCCC=CCC1C(CC(C1C=CC(CSC2=CCCCC2)O)O)O
Isomeric SMILES:COC(=O)CCC/C=C\CC1[C@H](C(CC1O)O)/C=C/[C@H](CSC2=CCCCC2)O

Technology Process of 16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester

There total 4 articles about 16-(Cyclohex-1-enylthio)-17,18,19,20-tetranor-pgf2-alpha methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 59739-48-9
16-(cyclohex-1-enylthio)-17,18,19,20-tetranorprostaglandin F_2α 9-acetate methyl ester

: 59739-49-0,73285-92-4
16-(cyclohex-1-enylthio)-17,18,19,20-tetranorprostaglandin F_2α methyl ester

Guidance literature:: With potassium carbonate; In methanol; at 40 - 45 ℃; for 1h;
DOI:10.1021/jm00179a010

Reference yield:

: 60894-66-8
<1α(Z), 2β(1E), 3α, 5α>-7-<5-(acetyloxy)-2-(2-formylethenyl)-3-<(tetrahydro-2H-pyran-2-yl)oxy>cyclopentyl>-5-heptenoic acid methyl ester

: 59739-49-0,73285-92-4
16-(cyclohex-1-enylthio)-17,18,19,20-tetranorprostaglandin F_2α methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1.) THF, hexane, 5 deg C, 3 h, 2.) THF, hexane, -78 deg C, 1 h

2: 70 percent / 65percent aq. acetic acid / tetrahydrofuran / 1 h / 40 °C

3: 85 percent / K₂CO₃ / methanol / 1 h / 40 - 45 °C

With n-butyllithium; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm00179a010

Reference yield:

: 4410-13-3
1-(methylthio)cyclohexene

: 59739-49-0,73285-92-4
16-(cyclohex-1-enylthio)-17,18,19,20-tetranorprostaglandin F_2α methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1.) THF, hexane, 5 deg C, 3 h, 2.) THF, hexane, -78 deg C, 1 h

2: 70 percent / 65percent aq. acetic acid / tetrahydrofuran / 1 h / 40 °C

3: 85 percent / K₂CO₃ / methanol / 1 h / 40 - 45 °C

With n-butyllithium; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm00179a010