Technology Process of 1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane
There total 7 articles about 1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 85 percent / diisopropyl ethylamine / CH2Cl2 / 4 h / Ambient temperature
2: 1.) Mg, I2 / 1.) THF, reflux, 1.5 h, 2.) THF, room temperature, 3 h
3: diisopropyl ethylamine / CH2Cl2 / 5 h / Ambient temperature
4: LiClO4, NaOAc / anodic oxidation at 1.3 V
5: LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temperature, 6 h
6: 95 percent / BCl3 / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) room temperature, 2 h
7: 91 percent / DCC, DMAP / CH2Cl2 / 96 h / Ambient temperature
With
dmap; iodine; sodium acetate; lithium perchlorate; boron trichloride; magnesium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(97)10196-X
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Mg, I2 / 1.) THF, reflux, 1.5 h, 2.) THF, room temperature, 3 h
2: diisopropyl ethylamine / CH2Cl2 / 5 h / Ambient temperature
3: LiClO4, NaOAc / anodic oxidation at 1.3 V
4: LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temperature, 6 h
5: 95 percent / BCl3 / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) room temperature, 2 h
6: 91 percent / DCC, DMAP / CH2Cl2 / 96 h / Ambient temperature
With
dmap; iodine; sodium acetate; lithium perchlorate; boron trichloride; magnesium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(97)10196-X