1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

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Chemical Name:1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane
CAS No.:200863-90-7
Molecular Formula:C₆₆H₆₄N₂O₁₈
Molecular Weight:1173.24
Hs Code.:

Synonyms:1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

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Chemical Property of 1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

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Technology Process of 1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

There total 7 articles about 1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 4-(4-Methoxy-benzyloxycarbonylamino)-cyclohexanecarboxylic acid

: 1,6-bis(1,4-dihydroxynthracene-9,10-dion-2-yl)-1,6-hexanediol

: 200863-90-7
1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 96h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10196-X

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 200863-90-7
1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / diisopropyl ethylamine / CH₂Cl₂ / 4 h / Ambient temperature

2: 1.) Mg, I₂ / 1.) THF, reflux, 1.5 h, 2.) THF, room temperature, 3 h

3: diisopropyl ethylamine / CH₂Cl₂ / 5 h / Ambient temperature

4: LiClO₄, NaOAc / anodic oxidation at 1.3 V

5: LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temperature, 6 h

6: 95 percent / BCl₃ / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) room temperature, 2 h

7: 91 percent / DCC, DMAP / CH₂Cl₂ / 96 h / Ambient temperature

With dmap; iodine; sodium acetate; lithium perchlorate; boron trichloride; magnesium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(97)10196-X

Reference yield:

: 73220-20-9
5-methoxy-2-(methoxymethoxy)benzaldehyde

: 200863-90-7
1,6-bis(1,4-dihydroxyanthracene-9,10-dion-2-yl)-1,6-bis[(trans-4-{N-[(4-methoxybenzyl)oxy]carbonyl}amino)cyclohexylcarbonyloxy]-hexane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Mg, I₂ / 1.) THF, reflux, 1.5 h, 2.) THF, room temperature, 3 h

2: diisopropyl ethylamine / CH₂Cl₂ / 5 h / Ambient temperature

3: LiClO₄, NaOAc / anodic oxidation at 1.3 V

4: LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) room temperature, 6 h

5: 95 percent / BCl₃ / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) room temperature, 2 h

6: 91 percent / DCC, DMAP / CH₂Cl₂ / 96 h / Ambient temperature

With dmap; iodine; sodium acetate; lithium perchlorate; boron trichloride; magnesium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(97)10196-X