(2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ⁴-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester

Base Information

• Chemical Name: (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ⁴-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester
• CAS No.: 60049-41-4
• Molecular Formula: C₁₉H₂₂N₂O₅S
• Molecular Weight: 390.46

Synonyms:(2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ⁴-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester

Chemical Property of (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ⁴-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ⁴-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester

There total 6 articles about (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ⁴-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-((1R)-2-benzoyl-3,3-dimethyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester (57704-07-1) → (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ4-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester (60049-41-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/ja00426a077

Reference yield:

(R)-2-((R)-3-benzoyl-2,2-dimethyl-thiazolidine-4-carbonylamino)-3-methyl-but-3-enoic acid methyl ester (61796-37-0) → (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ4-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester (60049-41-4)

Guidance literature:

Multi-step reaction with 4 steps

1: CCl₄

2: HCl / CH₂Cl₂

3: NaH / CH₂Cl₂; dimethylformamide

4: MCPBA / CH₂Cl₂

With hydrogenchloride; tetrachloromethane; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00426a077

Reference yield:

(R)-2-((4R)-3-benzoyl-5t-chloro-2,2-dimethyl-thiazolidine-4r-carbonylamino)-3-methyl-but-3-enoic acid methyl ester (60049-40-3) → (2R)-2-((1R)-2-benzoyl-3,3-dimethyl-4c,7-dioxo-(1rH,5cH)-4λ4-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester (60049-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / CH₂Cl₂; dimethylformamide

2: MCPBA / CH₂Cl₂

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja00426a077

upstream raw materials:

(2R)-2-((1R)-2-benzoyl-3,3-dimethyl-7-oxo-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-6-yl)-3-methyl-but-3-enoic acid methyl ester

(R)-2-((R)-3-benzoyl-2,2-dimethyl-thiazolidine-4-carbonylamino)-3-methyl-but-3-enoic acid methyl ester

(R)-2-((4R)-3-benzoyl-5t-chloro-2,2-dimethyl-thiazolidine-4r-carbonylamino)-3-methyl-but-3-enoic acid methyl ester

(R)-2-Amino-3-methyl-2-butensaeure-methylester

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