Technology Process of diethyl (1S,2S)-(1-benzyloxy-2-hydroxy-2-phenylethyl)phosphonate
There total 3 articles about diethyl (1S,2S)-(1-benzyloxy-2-hydroxy-2-phenylethyl)phosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl (1-benzyloxy-2-oxo-2-phenylethyl)phosphonate;
With
RuCl[(1R,2R)-p-TsNCH(C6H5)CH-(C6H5)NH2](η6-benzene); triethylamine;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
With
formic acid;
at 35 ℃;
for 2h;
Reagent/catalyst;
Solvent;
Time;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/jo500148j
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -5 - 0 °C / Inert atmosphere
2.1: triethylamine; RuCl[(1R,2R)-p-TsNCH(C6H5)CH-(C6H5)NH2](η6-benzene) / 0.17 h / 20 °C / Inert atmosphere
2.2: 2 h / 35 °C / Inert atmosphere
With
RuCl[(1R,2R)-p-TsNCH(C6H5)CH-(C6H5)NH2](η6-benzene); triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1021/jo500148j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 3 h / 130 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.75 h / -5 - 0 °C / Inert atmosphere
3.1: triethylamine; RuCl[(1R,2R)-p-TsNCH(C6H5)CH-(C6H5)NH2](η6-benzene) / 0.17 h / 20 °C / Inert atmosphere
3.2: 2 h / 35 °C / Inert atmosphere
With
RuCl[(1R,2R)-p-TsNCH(C6H5)CH-(C6H5)NH2](η6-benzene); triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1021/jo500148j
