methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

Base Information

Chemical Name:methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate
CAS No.:1613190-47-8
Molecular Formula:C₂₆H₂₈N₂O₂
Molecular Weight:400.521
Hs Code.:

Synonyms:methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

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Chemical Property of methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

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Technology Process of methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

There total 2 articles about methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613190-56-9
C₂₁H₂₂N₂O₂

: 81159-43-5
methanesulfonic acid pent-2-ynyl ester

: 1613190-47-8
methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 4h;
DOI:10.1002/chem.201304524

Reference yield:

: 4307-98-6
N-benzyltryptamine

: 1613190-47-8
methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 6 h / 20 °C

1.2: 1.25 h / 0 °C

2.1: potassium carbonate / acetonitrile / 4 h / 70 °C

With potassium carbonate; In tetrahydrofuran; acetonitrile; 1.1: |Pictet-Spengler Synthesis / 1.2: |Pictet-Spengler Synthesis;
DOI:10.1002/chem.201304524

Reference yield: 90.0%

: 1613190-47-8
methyl 2-(9-benzyl-2-(pent-2-ynyl)-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)acetate

: (E)-methyl 3-((Z)-7-benzyl-6-ethyl-1H-azocino[5,4-b]indol-3(2H,4H,7H)-yl)acrylate

Guidance literature:: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In toluene; at 110 ℃; for 2h; regioselective reaction;
DOI:10.1002/chem.201304524