5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid

Base Information

• Chemical Name: 5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid
• CAS No.: 1135372-45-0
• Molecular Formula: C₂₀H₁₆Br₂N₄O₇
• Molecular Weight: 584.178
• Mol file: 1135372-45-0.mol

Synonyms:5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid

Chemical Property of 5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid

There total 1 articles about 5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,3-dimethylbarbituric acid (769-42-6) + 2-bromo-1-bromomethyl-3-nitrobenzene (82617-49-0) → 5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid (1135372-45-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In chloroform; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1021/ol900016g

Reference yield: 69.0%

5,5-bis(2-bromo-3-nitrobenzyl)-1,3-dimethylbarbituric acid (1135372-45-0) → 2,2-bis(2-bromo-3-nitrobenzyl)-N,N'-dimethylmalonamide (1135372-63-2)

Guidance literature:

With sodium hydroxide; water; In ethanol; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/ol900016g

upstream raw materials:

1,3-dimethylbarbituric acid

2-bromo-1-bromomethyl-3-nitrobenzene

Downstream raw materials:

2,2-bis(2-bromo-3-nitrobenzyl)-N,N'-dimethylmalonamide

Refernces