N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine

Base Information

• Chemical Name: N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine
• CAS No.: 1338369-70-2
• Molecular Formula: C₁₇H₂₀BrN₃O₂
• Molecular Weight: 378.269
• Mol file: 1338369-70-2.mol

Synonyms:N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine

Chemical Property of N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine

There total 6 articles about N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-Bromopyridine (626-55-1,163928-56-1) + N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)diazene (1338369-61-1) → N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine (1338369-70-2)

Guidance literature:

3-Bromopyridine; With TurboGrignard; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)diazene; In tetrahydrofuran; at -100 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1055/s-0030-1260082

Reference yield:

N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)hydrazine (1338369-90-6) → N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine (1338369-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 0.33 h / -100 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; TurboGrignard; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0030-1260082

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)-N'-(pyridin-3-yl)hydrazine (1338369-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 20 °C / Inert atmosphere

2.1: pyridine; N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: TurboGrignard / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.2: 0.33 h / -100 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; TurboGrignard; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-0030-1260082

upstream raw materials:

3-Bromopyridine

N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)diazene

N-tert-butoxycarbonyl-N'-(2-bromo-4-methylphenyl)hydrazine

di-tert-butyl dicarbonate

Downstream raw materials:

N-(2-bromo-4-methylphenyl)-N-(pyridin-3-yl)hydrazine

N-(pyridin-3-yl)-2-bromo-4-methylaniline