Eflumast

Base Information

Chemical Name:Eflumast
CAS No.:70977-46-7
Molecular Formula:C10H8 F N5 O3
Molecular Weight:265.204
Hs Code.:
European Community (EC) Number:275-077-9
UNII:3CIG2V70UB
DSSTox Substance ID:DTXSID80867976,DTXSID50902267
Nikkaji Number:J288.716I
Wikidata:Q27257030
NCI Thesaurus Code:C73049
ChEMBL ID:CHEMBL153613
Mol file:70977-46-7.mol

Synonyms:eflumast;N-(2-hydroxy-3-acetyl-5-fluorophenyl)-5-carboxamido-1H-tetrazole;RP 42068;RP-42068;RP42068

Suppliers and Price of Eflumast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
EFLUMAST 95.00%
5MG
$ 496.10

Total 7 raw suppliers

Chemical Property of Eflumast

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:379.623°C at 760 mmHg
Flash Point:183.39°C
PSA：120.86000
Density:1.721g/cm³
LogP:0.57230
XLogP3:0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:265.06111730
Heavy Atom Count:19
Complexity:369

Purity/Quality:

98%Min ^*data from raw suppliers

EFLUMAST 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C(C(=CC(=C1)F)NC(=O)C2=NNN=N2)O

Technology Process of Eflumast

There total 7 articles about Eflumast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 70977-96-7
1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 3-acetyl-5-fluoro-2-hydroxy-anilide

: 70977-46-7
N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide

Guidance literature:: With trifluoroacetic acid; for 0.5h; Heating;
DOI:10.1021/jm00154a019

Reference yield: 63.0%

: 100245-24-7
1-Benzyl-1H-tetrazole-5-carboxylic acid (3-acetyl-5-fluoro-2-hydroxy-phenyl)-amide

: 70977-46-7
N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; at 20 ℃; under 3102.9 Torr;
DOI:10.1021/jm00154a019

Reference yield:

: 394-32-1
1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

: 70977-46-7
N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1H-tetrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / conc. HNO₃, conc. H₂SO₄ / -20 °C

2: 99 percent / H₂ / 5percent Pd/C / ethanol

3: pyridine / CH₂Cl₂ / 1 h / 20 °C

4: 63 percent / H₂, CH₃COOH / 5percent Pd/C / 20 °C / 3102.9 Torr

With pyridine; sulfuric acid; hydrogen; nitric acid; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00154a019