2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide

Base Information

• Chemical Name: 2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide
• CAS No.: 1004534-67-1
• Molecular Formula: C₁₈H₁₉BrN₂O₅S
• Molecular Weight: 455.329
• Mol file: 1004534-67-1.mol

Synonyms:2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide

Chemical Property of 2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide

There total 1 articles about 2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(4-bromo-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide (939022-07-8) + 1-bromo-3-propanol (627-18-9) → 2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide (1004534-67-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/jm070685e

Reference yield: 80.0%

2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide (1004534-67-1) → 2-(4-bromo-2-nitrophenylthio)-5-(3-fluoropropoxy)-N,N-dimethylbenzamide (1004534-77-3)

Guidance literature:

With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at -78 - 20 ℃; for 1h;

DOI:10.1021/jm070685e

Reference yield: 73.0%

2-(4-bromo-2-nitrophenylthio)-5-(3-hydroxypropoxy)-N,N-dimethylbenzamide (1004534-67-1) → 3-(3-((dimethylamino)methyl)-4-(4-bromo-2-nitrophenylthio)phenoxy)propanol (1004535-25-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm070685e

upstream raw materials:

2-(4-bromo-2-nitrophenylthio)-5-hydroxy-N,N-dimethylbenzamide

1-bromo-3-propanol

Downstream raw materials:

2-(4-bromo-2-nitrophenylthio)-5-(3-fluoropropoxy)-N,N-dimethylbenzamide

3-(4-(2-amino-4-bromophenylthio)-3-((dimethylamino)methyl)phenoxy)-1-propanol

3-(3-((dimethylamino)methyl)-4-(4-bromo-2-nitrophenylthio)phenoxy)propanol