methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

Base Information

Chemical Name:methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate
CAS No.:870470-49-8
Molecular Formula:C₁₉H₂₈N₂O₄Si
Molecular Weight:376.528
Hs Code.:

Synonyms:methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

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Chemical Property of methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

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Technology Process of methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

There total 1 articles about methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 104-87-0
4-methyl-benzaldehyde

: 166392-81-0
methyl 3-tert-butyldimethylsilyloxy-2-diazobut-3-enoate

: 870470-49-8
methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

Guidance literature:: scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 10h;
DOI:10.1021/ol052003s

Reference yield:

: 870470-49-8
methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

: 2-(tert-butyldimethysilanoxy)-2-hydroxymethyl-3-(p-tolyl)cyclobutanol

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂(OAc)4 / CH₂Cl₂ / 5 h / Heating

2: LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

With lithium aluminium tetrahydride; dirhodium tetraacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol052003s

Reference yield:

: 870470-49-8
methyl 5-(tert-butyldimethylsilanoxy)-2-diazo-5-(p-tolyl)-3-oxopentanoate

: 2-(tert-butyldimethysilanoxy)-2-hydroxymethyl-3-(p-tolyl)cyclobutanol

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂(OAc)4 / CH₂Cl₂ / 5 h / Heating

2: LiAlH₄ / tetrahydrofuran / 4 h / 20 °C

With lithium aluminium tetrahydride; dirhodium tetraacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol052003s