1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate
CAS No.:871338-85-1
Molecular Formula:C₁₇H₂₃ClN₂O₄
Molecular Weight:354.834
Hs Code.:

Synonyms:1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

There total 1 articles about 1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 108-37-2
1-bromo-3-chlorobenzene

: 129799-08-2
tert-butyl methyl piperazine-1,3-dicarboxylate

: 871338-85-1
1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 42h;

Reference yield: 76.0%

: 871338-85-1
1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

: 871338-86-2
1-(3-chlorophenyl)-4-{[(1,1-dimethylethyl)oxy]carbonyl}piperazine-2-carboxylic acid

Guidance literature:: With potassium hydroxide; water; In methanol; at 50 ℃; for 5h;

Reference yield:

: 871338-85-1
1-(1,1-dimethylethyl) 3-methyl 4-(3-chlorophenyl)piperazine-1,3-dicarboxylate

: 871464-69-6
1-(3-chlorophenyl)-N-(2-morpholin-4-ylethyl)piperazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; water / methanol / 5 h / 50 °C

2: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; HATU / N,N-dimethyl-formamide / 21 h / 25 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 0.03 h / Heating / reflux

With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; water; HATU; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;