[(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol

Base Information

• Chemical Name: [(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol
• CAS No.: 882043-95-0
• Molecular Formula: C₃₈H₄₂O₄
• Molecular Weight: 562.749
• Mol file: 882043-95-0.mol

Synonyms:[(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol

Chemical Property of [(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol

There total 2 articles about [(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → [(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol (882043-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethyl orthoformate / 3 h / 90 °C

2: tetrahydrofuran / 0 - 20 °C

With orthoformic acid triethyl ester; In tetrahydrofuran;

DOI:10.1021/ja056018x

Reference yield:

(2S,3S,6S,9R)-6-Isopropyl-9-methyl-1,4-dioxa-spiro[4.5]decane-2,3-dicarboxylic acid diethyl ester (882043-94-9) + phenylmagnesium bromide → [(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol (882043-95-0)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ja056018x

Reference yield:

[(2S,3S,6S,9R)-3-(Hydroxy-diphenyl-methyl)-6-isopropyl-9-methyl-1,4-dioxa-spiro[4.5]dec-2-yl]-diphenyl-methanol (882043-95-0) → C38H40ClO4P

Guidance literature:

With triethylamine; phosphorus trichloride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/ja056018x

upstream raw materials:

(2S,3S,6S,9R)-6-Isopropyl-9-methyl-1,4-dioxa-spiro[4.5]decane-2,3-dicarboxylic acid diethyl ester

(2R,5S)-menthone