1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

Base Information

Chemical Name:1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea
CAS No.:1209006-15-4
Molecular Formula:C₂₈H₃₉N₅O₃S
Molecular Weight:525.715
Hs Code.:

Synonyms:1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

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Chemical Property of 1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

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Technology Process of 1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

There total 7 articles about 1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1209006-91-6
(2-amino-1-benzothiophen-3-yl){4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}methanone

: 75-04-7,85404-22-4
ethylamine

: 1209006-15-4
1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

Guidance literature:: bis(trichloromethyl) carbonate; (2-amino-1-benzothiophen-3-yl){4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}methanone; With triethylamine; In chloroform; at 0 ℃; for 0.0833333h;

ethylamine; In chloroform; water; at 20 ℃; for 0.166667h;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1209006-77-8
(2-amino-1-benzothiophen-3-yl)(piperazin-1-yl)methanone

: 1209006-15-4
1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / chloroform / 16 h / 20 °C

2.1: hydrogenchloride / ethyl acetate / 48 h

3.1: triethylamine / chloroform / 1 h / 0 °C

4.1: triethylamine / chloroform / 0.08 h / 0 °C

4.2: 0.17 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1067908-08-0
tert-butyl 4-(2-aminobenzo[b]thiophene-3-carbonyl)piperazine-1-carboxylate

: 1209006-15-4
1-[3-({4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethyl acetate / 4 h

2.1: sodium tris(acetoxy)borohydride / chloroform / 16 h / 20 °C

3.1: hydrogenchloride / ethyl acetate / 48 h

4.1: triethylamine / chloroform / 1 h / 0 °C

5.1: triethylamine / chloroform / 0.08 h / 0 °C

5.2: 0.17 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2011.01.041