(R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: (R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone
• CAS No.: 1233690-38-4
• Molecular Formula: C₂₃H₂₁F₃N₄OS
• Molecular Weight: 458.507

Synonyms:(R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone

Chemical Property of (R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone

Chemical Property:

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Technology Process of (R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone

There total 1 articles about (R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

(R)-6-benzyl-2-phenethyl-4-(2,2,2-trifluoroacetyl)-4,5,6,7-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-one (1233690-39-5) → (R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone (1233690-38-4)

Guidance literature:

With Lawessons reagent; In toluene; at 70 ℃; for 2h;

Reference yield: 99.0%

(R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone (1233690-38-4) → (R)-6-benzyl-2-phenethyl-4,5,6,7-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-thione (1233690-40-8)

Guidance literature:

With sodium hydroxide;

Reference yield: 70.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + (R)-1-(6-benzyl-2-phenethyl-8-thioxo-5,6,7,8-tetrahydropyrazolo[4,3-e][1,4]diazepin-4(2H)-yl)-2,2,2-trifluoroethanone (1233690-38-4) → (R)-6-benzyl-2-phenethyl-N-(2-morpholinethyl)-2,4,5,6-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-amine (1233690-44-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

upstream raw materials:

(R)-6-benzyl-2-phenethyl-4-(2,2,2-trifluoroacetyl)-4,5,6,7-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-one

Downstream raw materials:

(S)-tert-butyl 3-((R)-6-benzyl-2-phenethyl-2,4,5,6-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-amino)pyrrolidin-1-carboxylate

(R)-6-benzyl-N-(1-benzylpiperidin-4-yl)-2-phenethyl-2,4,5,6-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-amine

(R)-6-benzyl-2-phenethyl-N-methyl-2,4,5,6-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-amine

(R)-6-benzyl-2-phenethyl-N-(2-(piperidin-1-yl)ethyl)-2,4,5,6-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-amine

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