N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

Base Information

Chemical Name:N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine
CAS No.:1332704-10-5
Molecular Formula:C₁₈H₂₃Cl₂N₅O₂
Molecular Weight:412.319
Hs Code.:

Synonyms:N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

Chemical Property:

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Technology Process of N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

There total 4 articles about N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1404222-98-5
N-(3,4-dichlorophenyl)-N'-(1-isopropyl-1H-imidazol-2-yl)guanidine hydrochloride

: 1332704-10-5
N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

Guidance literature:: With dmap; triethylamine; In chloroform; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm200503s

Reference yield:

: 1056619-71-6
1-(1-methylethyl)-1H-imidazol-2-amine

: 1332704-10-5
N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 18 h / 20 °C / Inert atmosphere

2: ammonia; mercury dichloride / methanol; N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3: dmap; triethylamine / chloroform / 18 h / 0 - 20 °C / Inert atmosphere

With dmap; ammonia; triethylamine; mercury dichloride; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm200503s

Reference yield:

: 1332704-15-0
1-(3,4-dichlorophenyl)-3-(1-isopropyl-1H-imidazol-2-yl)thiourea

: 1332704-10-5
N-(3,4-dichlorophenyl)-N'-(t-butyloxycarbonyl)-N''-(1-isopropyl-1Himidazol-2-yl)guanidine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia; mercury dichloride / methanol; N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2: dmap; triethylamine / chloroform / 18 h / 0 - 20 °C / Inert atmosphere

With dmap; ammonia; triethylamine; mercury dichloride; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm200503s