2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

Base Information

Chemical Name:2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione
CAS No.:77626-12-1
Molecular Formula:C₂₂H₂₂ClN₃OS₂
Molecular Weight:444.021
Hs Code.:

Synonyms:2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

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Chemical Property of 2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

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Technology Process of 2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

There total 4 articles about 2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-5-morpholin-4-yl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone

: 77626-12-1
2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane; H₂O / 1 h / 100 °C

2: sulphur / 3 h / Heating

With hydrogenchloride; sulfur; In 1,4-dioxane; water;

Reference yield:

: 81321-33-7
(E)-N-[2-(4-Chlorophenyl)ethenyl]morpholine

: 77626-12-1
2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CHCl₃ / 1.) 3h, reflux, 2.) room temp.

2: HCl / dioxane; H₂O / 1 h / 100 °C

3: sulphur / 3 h / Heating

With hydrogenchloride; sulfur; triethylamine; In 1,4-dioxane; chloroform; water;

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 77626-12-1
2-[4-(4-Chloro-phenyl)-1-(4-methylsulfanyl-phenyl)-1H-pyrazol-3-yl]-1-morpholin-4-yl-ethanethione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) diisobutylaluminum hydride 2.) sulphuric acid / 1.) toluene, -5 deg C, 1 h; 2.) ethanol, water

2: triethylamine / CHCl₃ / 1.) 3h, reflux, 2.) room temp.

3: HCl / dioxane; H₂O / 1 h / 100 °C

4: sulphur / 3 h / Heating

With hydrogenchloride; sulfuric acid; diisobutylaluminium hydride; sulfur; triethylamine; In 1,4-dioxane; chloroform; water;