1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea

Base Information

• Chemical Name: 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea
• CAS No.: 174497-06-4
• Molecular Formula: C₁₄H₂₃N₅O₂
• Molecular Weight: 293.369
• Mol file: 174497-06-4.mol

Synonyms:1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea

Chemical Property of 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea

There total 3 articles about 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2-{3-Methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-ureido}-ethyl)-carbamic acid tert-butyl ester (174497-04-2) → 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea (174497-06-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 3h;

DOI:10.1021/ja9536072

Reference yield:

N-(2-aminoethyl)benzeneamine (1664-40-0) → 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea (174497-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / H₂ / 10percent Pd/C / methanol / 16 h

2: 75 percent / CH₂Cl₂ / 11 h

3: 87 percent / CF₃CO₂H / CH₂Cl₂ / 3 h

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja9536072

Reference yield:

[2-(2-Phenylamino-ethylamino)-ethyl]-carbamic acid tert-butyl ester (174497-02-0) → 1-(2-Amino-ethyl)-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea (174497-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / CH₂Cl₂ / 11 h

2: 87 percent / CF₃CO₂H / CH₂Cl₂ / 3 h

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja9536072

upstream raw materials:

(2-{3-Methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-ureido}-ethyl)-carbamic acid tert-butyl ester

N-(2-aminoethyl)benzeneamine

[2-(2-Phenylamino-ethylamino)-ethyl]-carbamic acid tert-butyl ester

Downstream raw materials:

1-[2-(2-Cyano-ethylamino)-ethyl]-3-methyl-1-[2-(3-methyl-1-phenyl-ureido)-ethyl]-urea