2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid

Base Information

Chemical Name:2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid
CAS No.:1370705-94-4
Molecular Formula:C₂₇H₂₆F₂N₄O₅
Molecular Weight:524.524
Hs Code.:

Synonyms:2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid

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Chemical Property of 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid

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Technology Process of 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid

There total 2 articles about 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: ethyl 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetate trifluoroacetic acid semi-salt

: 1370705-94-4
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: ethyl 2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetate trifluoroacetic acid semi-salt; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With trifluoroacetic acid; In water; pH=2;
DOI:10.1016/j.ejmech.2012.01.059

Reference yield:

: 1370706-23-2
ethyl 2-((2-((4-cyanophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetate

: 1370705-94-4
2-((2-((4-carbamimidoylphenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)(3,4-difluorobenzyl)amino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol / 24.5 h / 20 °C

1.2: 24 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

2.2: pH 2

With hydrogenchloride; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; 1.1: Pinner amidine synthesis / 1.2: Pinner amidine synthesis;
DOI:10.1016/j.ejmech.2012.01.059